https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27945 Puma-dependent neuronal apoptosis. Of particular importance to the developing brain is the direct NMDAR-dependent transcriptional control of glutathione biosynthesis, disruption of which can lead to degeneration. Notably, these activity-dependent cell-autonomous mechanisms were found to cooperate with non-cell-autonomous Nrf2-driven support from astrocytes to maintain neuronal GSH levels in the face of oxidative insults. Thus, developmental NMDAR hypofunction and glutathione system deficits, separately implicated in several neurodevelopmental disorders, are mechanistically linked.]]> Wed 11 Apr 2018 14:57:38 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17140 Wed 11 Apr 2018 13:06:31 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22665 Wed 11 Apr 2018 12:37:33 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22750 Wed 11 Apr 2018 10:56:04 AEST ]]>